The Curbsiders Internal Medicine Podcast

#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

Mon, 16 Mar 2026

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Alex Chaitoff (@alexchaitoff), Nora Taranto (@norataranto), & Matt Watto (@doctorwatto).

Claim CME for this episode at curbsiders.vcuhealth.org!

Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP

Cover Art: Nora Taranto MD, MSCE

Reviewer: Sai S Achi MD, MBA, FACP

Technical Production: Pod Paste

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Show Segments

Intro, disclaimer

GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT

Weight Regain after Weight loss

VALAD – Valacyclovir in patients with early Alzheimer’s

Nudges to increase Deprescribing

Outro

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REBOOT: #481 Prediabetes and Diabetes Prevention with Dr. Scott Isaacs

Mon, 09 Mar 2026

We have a classic episode for you. Conquer prediabetes and diabetes prevention! We’re joined by Dr. Scott Isaacs, who provides essential pearls on navigating screening tests for diabetes and prediabetes, identifying atypical cases of prediabetes, and individualizing management of prediabetes with lifestyle changes and medications.

Intro

Case from Kashlak

Why screen for prediabetes and diabetes?

Who to screen for prediabetes and diabetes

How to screen for prediabetes and diabetes

Role of the physical exam

Explaining a diagnosis of prediabetes to patients

Atypical types of prediabetes

Management of prediabetes: lifestyle changes

Management of prediabetes: medications

Outro

Credits

Producer, Writer, and Show Notes: Malini Gandhi MD

Infographic and Cover Art: Zoya Surani

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP

Reviewer: Sai Achi MD,MBA,FACP

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Scott Isaacs MD

Disclosures

Dr. Isaacs reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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#516 Lyme Disease Primer featuring Dr. Sophie Woolston

Mon, 02 Mar 2026

Stop getting TICK’ed off by Lyme

Master Lyme disease — from recognizing erythema migrans and avoiding unnecessary testing to managing disseminated Lyme and post-exposure prophylaxis. Learn practical, evidence-based strategies you can use in the clinic. We’re joined by Dr. Sophie Woolston MD, infectious diseases expert and clinician-educator. (MaineHealth)

Claim CME for this episode at curbsiders.vcuhealth.org!

Intro

Case 1

Lyme Basics

Stages of Lyme

Lyme Testing and Interpretation

Coinfection

Lyme Treatment

Tick Prevention and Removal

Post-Treatment Lyme Disease Syndrome

Outro

Credits

Written and Produced by: Beth Gasperlin MD

Show Notes, Infographics, and Cover Art by: Zoya Surani

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP, Beth Gasperlin MD

Reviewer: Leah Witt MD

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Sophie Woolston MD

Disclosures

Dr. Woolston reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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#515 Primary Aldosteronism, A Deep Dive with Anand Vaidya, MD

Mon, 23 Feb 2026

Helping you diagnose a common cause of hypertension!

Hypertension is a growing disease globally, affecting millions of individuals and increasing the risk of heart disease and stroke. Along with the expert help of Dr. Vaidya (Brigham and Women’s Hospital), we help reimagine the approach of clinicians in terms of hypertension and help them navigate common diagnostic dilemmas! @AnandVaidya17 (Bluesky) @AnandVaidya17 (X)

Introduction and Personal Interests

Advice and Wisdom in Medicine

Case 1

Defining Primary Aldosteronism

Screening for Primary Aldosteronism

How common is Primary Aldosteronism

Challenges in Diagnosis and Testing

Medication Management and Testing Protocols

Managing indeterminate cases

Aldosterone Suppression Testing and its role

Discussing treatment options with patients

Case 2

Considering genetic causes of Primary Aldosteronism

The need for AVS for lateralization

Upcoming imaging modalities for Primary Aldosteronism

Case 3

Medical Management of Primary Aldosteronism

Future Directions in Treatment

Credits

Producer, Writer, Show Notes:Mobeen Ahmad MBBS

Infographic:Kate Grant MBChB MRCGP

Cover Art:Kate Grant MBChB MRCGP

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP

Reviewer: Emi Okamoto MD

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Anand Vaidya MD, MMSc

Disclosures

Dr. Vaidya has disclosed the following:

Financial Relationships: Astra Zeneca-Consulting Fee and Corcept-Consulting Fee, relationships have not ended.

The Curbsiders report no relevant financial disclosures.

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#514 Hotcakes: Oral Semaglutide, Fish Oil in ESRD, IV Iron During Infection, New US Dietary Guidelines, & Anticoagulation after Ablation in AFib

Mon, 16 Feb 2026

Join us as we review and appraise recent practice-changing articles on oral semaglutide for obesity, fish oil in ESRD, IV iron during infection, the new US Dietary Guidelines, & anticoagulation after ablation in AFib. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Rahul Ganatra (@rbganatra), Josh Gilman, & Matt Watto (@doctorwatto).

Claim CME for this episode at curbsiders.vcuhealth.org!

Written and Hosted by: Rahul Ganatra MD, MPH; Paul Williams, MD, FACP, Joshua Gilman, MD, & Matthew Watto MD, FACP

Cover Art: Rahul Ganatra, MD MPH

Reviewer: Emi Okamoto, MD

Technical Production: Pod Paste

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Show Segments

Intro, disclaimer

Oral Semaglutide for obesity

Fish Oil for CV risk reduction in hemodialysis patients

IV Iron for iron deficiency anemia during infection

New USA Dietary Guidelines

Anticoagulation after catheter ablation for AF

Outro

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